European champions Italy endured a humiliating night in Monchengladbach, as they were thrashed 5-2 by Germany in the UEFA National League.
Italy moved a point clear at the top of Group A3 after a 2-1 win over Hungary in their Nations League clash in Cesena.
World champions France held out with 10 men to draw 1-1 against Bosnia and Herzegovina in Strasbourg to consolidate their position at the top of Group D.
France were held by Ukraine as the defence of their World Cup title started with a 1-1 draw in Paris, while Tomas Soucek scored a hat-trick for Czech Republic.
Romelu Lukaku scored twice as Belgium beat Denmark 4-2 on Wednesday to book a spot in the Nations League's finals.
Arsenal defender Sead Kolasinac has tested positive for Covid-19 while on international duty with Bosnia and Herzegovina.
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