Preston claimed the West Lancashire bragging rights by cruising to a 3-1 victory over their relegation-threatened rivals Blackpool.
Cameron Archer struck twice against Preston to help secure a 4-0 win for Middlesbrough that has closed the gap on second-placed Sheffield United to three points.
Middlesbrough missed the chance to close the gap on Sheffield United in second as they were held to a 1-1 draw by Stoke. Elsewhere, Blackpool thumped six past QPR.
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